Search results for " follistatin"

showing 3 items of 3 documents

Serum follistatin in patients with prostate cancer metastatic to the bone

2010

The clinical significance of circulating fol- listatin (FLST), an inhibitor of the multifunctional cytokine activin A (Act A), was investigated in patients with prostate cancer (PCa). The serum concentrations of this molecule were determined by an enzyme-linked immunosorbent assay (ELISA) in PCa patients with (M?) or without (M0) bone metastases, in patients with benign prostate hyperplasia (BPH) and in healthy sub- jects (HS). The effectiveness of FLST in detecting PCa patients with skeletal metastases was determined by the receiver operating characteristic (ROC) curve analysis. Serum FLST was significantly higher in PCa patients than in BPH patients (P = 0.001) or HS (P = 0.011). Converse…

MaleCancer Researchmedicine.medical_specialtyFollistatinBone diseaseSettore MED/06 - Oncologia MedicaBone metastasis cancer follistatin prostate cancer transforming growth factor beta tumor markersBone Neoplasmsurologic and male genital diseasesGastroenterologySensitivity and SpecificityProstate cancerInternal medicineMedicineHumansClinical significanceAgedHematologybusiness.industryCancerBone metastasisProstatic NeoplasmsGeneral MedicineHyperplasiaMiddle AgedProstate-Specific Antigenmedicine.diseaseActivinsProstate-specific antigenEndocrinologyOncologySettore BIO/14 - Farmacologiabusiness
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Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

2018

How humans got their goatsLittle is known regarding the location and mode of the early domestication of animals such as goats for husbandry. To investigate the history of the goat, Dalyet al.sequenced mitochondrial and nuclear sequences from ancient specimens ranging from hundreds to thousands of years in age. Multiple wild populations contributed to the origin of modern goats during the Neolithic. Over time, one mitochondrial type spread and became dominant worldwide. However, at the whole-genome level, modern goat populations are a mix of goats from different sources and provide evidence for a multilocus process of domestication in the Near East. Furthermore, the patterns described suppor…

0301 basic medicineFollistatinMESH: DomesticationAGRICULTURE1103CATTLEMESH: FollistatinMESH: AfricaGenome[SHS]Humanities and Social SciencesDomestication0601 history and archaeologyMESH: AnimalsMESH: Genetic VariationMESH: PhylogenyPhylogenyZAGROSmedia_common2. Zero hunger[SDV.EE]Life Sciences [q-bio]/Ecology environmentGenome1311MultidisciplinaryMiddle East060102 archaeologyMosaicismMESH: AsiaGoats06 humanities and the artsEuropeAnimals DomesticMESH: MosaicismReproductionTRAITSAsia[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistorymedia_common.quotation_subject1204BiologyDNA MitochondrialMESH: GoatsMosaic03 medical and health sciencesPhylogeneticsGenetic variationAnimalsMESH: GenomeMESH: Animals DomesticDNA AncientDietary change[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Domestication[SDV.GEN]Life Sciences [q-bio]/GeneticsNEAR-EASTMESH: DNA MitochondrialGenetic VariationMESH: DNA AncientGENEMODEL030104 developmental biologySHEEPEvolutionary biologyORIGINSAfricaMESH: EuropeScience
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Follistatin as potential therapeutic target in prostate cancer

2012

Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins. Emerging evidence indicates that this molecule may also play a role in the malignant progression of several human tumors including prostate cancer. In particular, recent findings suggest that, in this tumor, follistatin may also contribute to the formation of bone metastasis through multiple mechanisms, some of which are not related to its specific activin or bone morphogenic proteins' inhibitory activity. This review provides insight into the most recent advances in understa…

MaleFollistatinendocrine systemCancer Researchmedicine.medical_specialtyanimal structuresGlycosylated proteinProstate cancerInternal medicinemedicineAnimalsHumansPharmacology (medical)Molecular Targeted TherapyActivin Bone metastasis.Cancer . Follistatin Prostate cancerbiologybusiness.industryProstatic NeoplasmsCancerBone metastasisSUPERFAMILYmedicine.diseaseEndocrinologyOncologyembryonic structuresDisease Progressionbiology.proteinCancer researchbusinesshormones hormone substitutes and hormone antagonistsFunction (biology)FollistatinTransforming growth factor
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